Adolescent suicide prevention requires a comprehensive and evidence-based approach that addresses the complex biological, psychological, social, and environmental factors affecting young people. Effective strategies include early identification through routine mental health screening, increasing mental health awareness and emotional resilience, strengthening family and peer support systems, and ensuring timely access to professional mental healthcare services. Additional preventive measures focus on promoting safe digital practices, reducing exposure to cyberbullying and harmful online content, restricting access to lethal means, and implementing clear crisis response and postvention protocols within schools and communities. Collaborative efforts among healthcare providers, educators, policymakers, and community organizations are essential to create supportive environments that reduce risk, encourage help-seeking behavior, and promote long-term mental wellbeing among adolescents.